Large protein molecules such as growth factors, cytokines and therapeutic antibodies can be formulated into parenteral depot formulations with release of structurally intact proteins  with preserved activity from several days up to 6 months. For this, we make use of our SynBiosys® platform which has several formulation possibilities, including microparticles, implants or coatings.

Key benefits

• Protection of protein by the matrix from environmental influences, like proteases

• Protection of protein from high shear forces during processing

• Protection of protein from increased temperature (during processing and storage)

InnoCore’s sustained release technologies are capable of releasing peptides structurally intact over a period of time, ranging from days to several weeks. Using either our SynBiosys® or InGell® polymer platform, the release is controlled by diffusion which can be tuned by variation of the SynBiosys® or InGell® building blocks ratio resulting in limited or no burst.

Key benefits

• No accumulation of acidic degradation products, allowing peptides to remain structurally intact

• Several formulation possibilities, including microspheres, gels, coatings and implants

• Protection of peptide from high shear forces during processing

InnoCore has several sustained release technologies that can easily be tailored to allow sustained release of small molecules. They can be used for local as well as for systemic drug delivery of small molecules for up to 6 months.

Key benefits

• No accumulation of acidic degradation products
• High loadings (40-50%)
• For gels, easy process and scale up conditions
• Several formulation possibilities, including microspheres, gels, coatings and implants