Drug modalities

Oligonucleotides – engineering the next generation of long-acting, high impact oligonucleotide therapeutics

Oligonucleotides – short, synthetic strands of nucleic acids – are gaining momentum as powerful therapeutic agents to treat a wide range of diseases. They are not naturally suited to long-acting dosage forms since they are inherently instable, susceptible to enzymatic degradation and poor cellular uptake.

Oligonucleotides - Innocore Solutions About Oligonucleotides

Oligonucleotides – short, synthetic strands of nucleic acids – are gaining momentum as powerful therapeutic agents to treat a wide range of diseases. They are not naturally suited to long-acting dosage forms since they are inherently instable, susceptible to enzymatic degradation and poor cellular uptake.

SynBiosys®, our advanced polymer platform, protects these sensitive molecules, extending their therapeutic exposure, and allowing for tailored release profiles.

RNA illustration

Which molecules can we work with?

Examples of Oligonucleotides

  • RNA and DNA fragments
  • Antisense oligonucleotides (ASO)
  • Aptamers

The benefits of using SynBiosys® for oligonucleotides

  • Applicable across oligonucleotides and chemically modified oligonucleotides e.g. antisense oligonucleotides (ASO) or aptamers
  • Protects API bioactivity by preserving structural integrity; also protects from physiological degradation e.g. enzymatic digestion
  • Low burst and tunable release durations, from several days up to 3 months
  • High encapsulation efficiency (>80%)
  • High API loadings compared to other formulation technologies (up to 20-30%)
  • Customisable formulations to optimise each drug product’s desired characteristics for efficacy and tolerability
  • Fully biocompatible and safe, with an extensive biocompatibility / toxicity data package
  • Easy-to-scale for manufacturing
  • Less API required vs traditional formulations, therefore, reducing cost of goods and environmental footprint
  • Varied dosage forms: microspheres, injectable implants, and in-situ forming depots, subcutaneous and intra-articular
  • Therapeutic focus: oncology, cardiovascular, CNS, rare diseases, infectious diseases, liver disease, ophthalmology, pulmonary & inflammatory disease, musculoskeletal disorders
Discover SynBiosys®

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